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This stratified response supports the concept of personalized microbiome-based interventions, as brought up by previous research, and suggests that host microbial context is a key determinant of probiotic efficacy rather than supplementation acting as a universally effective therapy

Research from obesity pharmacotherapy trials consistently shows that higher protein intake (targeting 0.8-1.0 grams per pound of goal body weight daily) significantly improves lean mass retention during rapid weight loss

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Another potential pathway that enhances FXR activity involves the release of the growth factor fibroblast growth factor (FGF) 19 from the intestine upon bile acid binding to FXR, 66 which has shown beneficial effects on MASH in animal models, although results are conflicting

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There is no requirement to take supplements under the supervision of a health professional