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Components of the extrinsic pathway include the death receptors FasR/FasL, DR4/DR5, and tumor necrosis factor (TNF) [20], whereas the intrinsic pathway centers on the Bcl-2 family of proteins which comprises both proapoptotic proteins, such as Bax, Bak, and Bid and antiapoptotic proteins, such as Bcl-2 and Bcl-xL [18, 19]
Moreover, the ligands are suitable for in vivo studies , as they are guaranteed sterile , verified using a European Pharmacopoeia-based (2.6.1) sterility assay
Genetic factors affecting GLP-1 receptor sensitivity are an area of ongoing research but currently have limited clinical utility for routine care
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(PDF) Webb, C.A., Auerbach, R.P., Bondy, E., Stanton, C.H., Appleman, L., Pizzagalli, D.A
Lancet 394 , 737745 (2019)
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