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Cureus 16(7): e64738

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The US Food and Drug Administration (FDA) has requested the removal of information regarding the risk of suicidal ideation and behavior (SI/B) from the labeling of glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications that currently include such language

Importantly, preclinical studies demonstrated that the synergistic effect of GIPRAs and GLP-1RAs on body weight requires the GABAergic (GABA refers to gamma-aminobutyric acid) GIPR-expressing neurons in the CNS [21, 28]

Pfizer acknowledged that the elevated liver enzymes observed in its trial were in line with rates seen in other approved GLP-1 medications

Bottom line: If you want to maximize the effects of glutathione, quality and consistency are more important than taking the highest possible dose