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Vitamin B12 Deficiency Since your body reserves some vitamin B12, a deficit may not manifest for several years
In the REDEFINE 1 trial, 79.6% of combination participants experienced GI events versus 39.9% on placebo
Age Older individuals may take longer to notice benefits due to decreased absorption and metabolic rates
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Dosing information Usual Adult Dose for Pernicious Anemia: Initial dose: 100 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days If clinical improvement and reticulocyte response is seen from the above dosing: 100 mcg every other day for 7 doses, then: 100 mcg every 3 to 4 days for 2 to 3 weeks, then: Maintenance dose: 100 to 1000 mcg monthly Duration of therapy: Life Comments: Administer concomitant folic acid if needed
This is BPC-157's strongest studied application
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