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86 OhashiR.TamaiI.YabuuchiH.NezuJ
One theoretical concern: aggressive caloric restriction accompanying drug-induced satiety reduction could suppress gonadotropins in women with low body fat reserves
Semaglutide works by attaching to GLP-1 receptors in the body
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Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014
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