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471 According to the PAKT trial, the addition of the AKT inhibitor capivasertib to the first-line paclitaxel therapy for TNBC resulted in significantly longer PFS and OS, especially in tumors with PIK3CA/AKT1/PTEN alterations

Cancer 39 , 9961003 (2003)

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This was despite qRT-PCR analysis showing no CRISPRi silencing effect in the bla PenB mutant, which we attribute to assessing expression without -lactamase exposure 66

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