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It is synthesized as a proreceptor that is cleaved into alpha and beta chains and assembled into a covalent heterotetramer, two alpha subunits and two beta subunits held together by disulfide bonds, which sits in the membrane as a preformed dimer even in the absence of ligand

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It said Ozempic (semaglutide injection) and Rybelsus (oral semaglutide) are the only GLP-1 medications currently listed, and these require special authorization for the treatment of type 2 diabetes

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