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Beyond this BMI range, however, it becomes increasingly unlikely that patients will achieve the level of weight loss necessary for the health outcomes they and their care team hope for with the medication alone

Jastreboff et al., 2022

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In most cases, GLP-1 drugs are prescribed alongside lifestyle changes like a healthy diet and physical activity to help people lose weight and manage their weight and blood sugar long-term

For example, a patient with obesity starting a GLP-1 medication who also has a personal history of DVT and takes oral contraceptives carries substantially higher baseline risk than someone with obesity alone

Most patients present with multiple comorbidities hypertension, type 2 diabetes, joint pain, osteoporosis, and more often requiring half a dozen or more medications