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A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus

Outcomes In the overall analysis, the risk of MACE was reduced by 14% (HR = 0.86, 95% CI, 0.790.94, P = 0.006) compared with placebo with no significant heterogeneity between trials (I 2 = 50.0%, P = 0.08) (Fig

Phe13 in subunit A has moved closer to the active site with a distance between the two C positions of 0.9

Slows digestion Promotes gradual nutrient absorption

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With repeated dosing, mean IGF-1 levels remained above baseline for up to 28 days