The second approved indication is for chronic weight management in adults with obesity (BMI 30 kg/m) or those who are overweight (BMI 27 kg/m) with at least one weight-related comorbidity, such as hypertension, dyslipidaemia, or obstructive sleep apnoea
Zhang M et al
Nature Medicine SURMOUNT-3 Meta-analisi 2024
Randomized trials, systematic reviews, meta-analyses, clinical guidelines, observational studies, and mechanistic or translational studies were prioritized when they directly informed obesity-related KOA, GLP-1RA therapy, rehabilitation, surgical optimization, safety, or implementation
(2014) 3:e001075
In one 24-week study, semaglutide users saw significant increases in total and free testosterone, along with better sperm shape and motility ( J Clin Endocrinol Metab , 2023)