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Critically, AOD-9604 does not elevate IGF-1 levels or impair glucose metabolism, distinguishing it from full-length GH

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(2013) Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans J Endocrinol Metab 3(12):715 AOD9604 vs Related GH-Axis Research Tools AOD9604s unique combination of GH receptor independence, direct lipolytic activity, absence of IGF-1 stimulation, and confirmed oral bioavailability makes it an irreplaceable research tool for studying adipose tissue metabolism and lipolysis without the systemic endocrine confounds associated with intact hGH or indirect GH secretagogues

Concentrations and dosing frequency vary by study but usually involve controlled topical administration in cosmetic or dermatological models