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Retatrutides Phase 2 monotherapy weight loss (~24.2% at 48 weeks) is numerically larger than cagrilintides (~10.8% at 26 weeks), but those come from different trials, durations, and doses, and cagrilintides strongest data are as the CagriSema combination

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The SNPs can affect vitamins B6, B12, and folate, whereas vitamins B1, B2, B3, B5, and B7 are not affected by the MTHFR variants