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The article says semaglutide activates the GLP-1 receptor, which regulates appetite, blood sugar, and gastric emptying, while tirzepatide adds activation of the GIP receptor, which influences insulin secretion and energy metabolism

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The injectable version was first approved by the FDA to help people who are overweight or have obesity manage their weight, especially those with related health conditions like high blood pressure, high cholesterol, or Type 2 diabetes

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