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Initial in vitro and in vivo pharmacology studies were focused on melanoma due to its established link with FAK signaling

Summary Cellular senescence, marked by irreversible cell cycle arrest and the secretion of proinflammatory factors, contributes to aging and cancer recurrence

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Yoshizawa et al

FAK-paxillin signaling is a well-characterized pathway through which cells coordinate adhesion turnover, focal adhesion remodeling, and migration