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On GLP-1, digestion is slower and less predictable
This stepwise escalation is designed to reduce gastrointestinal side effects during treatment initiation
Some protocols split the daily dose into morning and evening injections
Cost-Effectiveness: Dosing protocols are adjusted for each patient to maximize benefits while minimizing unnecessary costs
NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity
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