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2 Before the GLP-1 era: the traditional treatment pathway and its limitations Before the emergence of GLP-1-based anti-obesity pharmacotherapy, obesity-related KOA was generally managed within the same stepwise framework used for KOA overall, although overweight or obesity was explicitly recognized as a modifiable therapeutic target

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For most patients, the metabolic benefits

Together, these effects make it easier for patients to eat less and maintain a calorie deficit

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