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Oral semaglutide begins at 3 mg daily, increases by 3 mg weekly until reaching 7 mg daily, then steps up to 14 mg daily for maintenancea longer titration requiring daily pill adherence and must be taken on an empty stomach

They compared people who had begun taking a GLP-1 medication for other reasons, like weight loss, within a year of receiving a diagnosis of chronic migraine to individuals who started taking topiramate during the same period

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Depending on the individual medicine and its FDA-approved indication, GLP-1 receptor agonists may: Stimulate insulin release when blood glucose is elevated Reduce glucagon secretion Slow stomach emptying Increase feelings of fullness Support lower blood glucose Help some patients reduce body weight Semaglutide is a GLP-1 receptor agonist available in several prescription products

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