Several NADs, including ASOs, aptamers, siRNAs, and mRNA vaccines, have been adopted as vaccines for treating rare genetic diseases, cancer, ophthalmic diseases, CVDs, and infections
Briefly, at typical physiological GSH concentrations and pH, the reaction between ONOO - and GSH will predominantly be a two electron oxidation process leading to GSSG formation (Quijano et al., 1997)
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For a 2.5mg starting dose, that one-unit error represents a 16% dose change