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Only around 0.1% of endogenous oxalate arises from glycine catabolism, whereas approximately 15% of the daily endogenous production of glyoxylate derives from 4-hydroxyproline

However, animal studies have shown systemic effects with oral ingestion and caution is needed

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Prescription topical GHK-Cu does not require cycling off, because the collagen-stimulating effects reward uninterrupted daily use

"Regulation of cellular glutathione"