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Excessive FAs in the circulatory system promote insulin secretion from pancreatic beta cells, upregulate the expression of renal uric acid reabsorption proteins Glucose transporter type 9 (GLUT9) and urate transporter 1 (URAT1), and reduce the level of uric acid excretion protein ATP-binding cassette transporter G2 (ABCG2), resulting in elevated serum uric acid levels ( Figure 4 )

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From this run, we analyzed the evolution of the root mean square deviation (RMSD) of the atomic coordinates for both interacting proteins as well as persistent intermolecular contacts, defined as the distances between protein/ligand heavy atoms, which do not exceed 3 and exist in at least 80% of all trajectory frames

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Meanwhile, the concentration of CCL11 in culture supernatants was measured by ELISA

For injury healing protocols, refer to the Injury Protocols guide to design the appropriate stack