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Taken together, the evidence suggests that class-wide disease modification in Parkinsons, at the compounds and doses tested so far, is unlikely, even if a responder subgroup may yet exist
It is not a permanent change on its own
Most symptoms are mild to moderate, transient, and resolve within 4-8 weeks as physiologic tolerance develops
Sleep improvement is typically the earliest noticeable benefit
That can happen when sleep is fragmented, or when breathing events break up sleep without a full wake
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