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K-means clustering was performed on the genera relative abundance data using the R script in the Supplementary Materials Scripts .zip file (KMScript), and clusters were plotted

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Tesamorelin: Another growth hormone-releasing hormone analog studied specifically for visceral fat reduction

These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism