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Clinically, pain, deformity, and functional limitation predominate and markedly reduce quality of life (Binvignat et al., 2024)
The intertwined roles of PERK and IRE1 in angiogenesis, EMT, dormancy, and therapy resistance emphasize why indiscriminate UPR inhibition is unlikely to succeed clinically and why pathway-selective, context-aware strategies are needed
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10.1016/S0891-5849(97)00165-2 313 ZhangW
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