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This article outlines an approach to interpreting and working up a high serum B12 in adults by separating four possibilities: intake-related elevation, disease-associated hypercobalaminemia (an elevated blood B12 associated with an underlying condition), analytical interference, and functional deficiency

For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

Vitamin B12 is an essential nutrient for good health

Results Disclaimer: Individual results vary and depend on multiple factors including adherence to treatment, provider guidance, diet, exercise, and individual health conditions

Nat Commun 2017