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While numerous proof-of-concept candidate molecules have been disclosed (3443), the only approved example of multi-receptor agonism for obesity and T2D is the dual GLP-1R/GIPR co-agonist tirzepatide (marketed as Mounjaro and Zepbound ) (34, 44)

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IGF-1 directly activates satellite cells responsible for muscle fiber repair and growth

Once inside the mitochondria the fatty acyl-CoAs can be oxidized for energy production

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