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Within the context of concurrent GLP-1R and GIPR agonism, however, preclinical energy-expenditure models suggest that GCGR engagement may contribute to resting metabolic rate modulation and fatty-acid oxidation in hepatic cell lines

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The first FDA-approved GLP-1 receptor agonist, exenatide, was introduced for type 2 diabetes in 2005 and required twice-daily injections