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The glucagon receptor activation at this dose level also increases resting heart rate by up to 6.7 beats per minute and may trigger dysesthesia (tingling or burning skin sensations) reported in 8.8% to 20.9% of participants at higher doses in Phase 3 trials

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However, when these differences were compared via the KaplanMeier logarithmic rank test, they were not significant ( p = 0.127) (see Figs