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If this signal holds across TRIUMPH-1, TRIUMPH-2, and TRIUMPH-3, retatrutide could end up with a lipid profile that no other compound in the class shares

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For most people, weight loss continues as they stay on the medication (with more weight loss happening at higher doses) for about a year, at which point their weight loss levels off

Circulation 129(5):587597 van Bommel EJ, Muskiet MH, van Baar MJ, Tonneijck L, Smits MM, Emanuel AL et al (2019) The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial

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