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Severe gastrointestinal conditions: Those with delayed gastric emptying, gastroparesis, or chronic GI dysmotility may experience exacerbated symptoms due to the drugs action on gastric motility

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Over several months, patients often experience dramatic weight losswith studies and clinical trials showing up to 15% body weight reduction in certain cases

The possible effect of insulin therapy as a risk factor for thyroid cancer comes from pre-clinical data suggesting that insulin signaling is a key mediator in thyroid cancer cell growth

Others deal with persistent nausea that makes eating difficult and can lead to dehydration if not managed properly