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As a vital constituent of antigen-presenting cells (APCs), macrophage possesses two exact opposite-in-function phenotypes, M1 and M2, the former polarized by lipopolysaccharide (LPS), producing pro-inflammatory cytokines such as IL-1, IL-6, IL-12, IL-23, and TNF-, the latter polarized by Th2 cytokines, producing anti-inflammatory cytokines such as IL-10 and TGF- [20]
These are potential effects studied in clinical research, not guaranteed outcomes
First identified in the 1990s during research into gastric mucosal protection, BPC-157 has since been studied in numerous animal models for its seemingly broad healing properties
J Diabetes Res 2018:1232583 Ikonomidis I, Pavlidis G, Thymis J, Birba D, Kalogeris A, Kousathana F, Kountouri A, Balampanis K, Parissis J, Andreadou I, Katogiannis K, Dimitriadis G, Bamias A, Iliodromitis E, Lambadiari V (2020) Effects of glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, and their combination on endothelial glycocalyx, arterial function, and myocardial work index in patients with type 2 diabetes mellitus after 12-month treatment
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