Additionally, the succinate dehydrogenase (SDH), also located in the TM, reduces the PQ pool by oxidizing succinate to fumarate (Lea-Smith et al., 2016)
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Also, several pathogenic mechanisms linked to ALS involve redox-sensitive proteins, including protein disulfide isomerase (PDI), thioredoxin, and glutathione (GSH), and recent evidence highlights their importance in neurodegeneration
Corresponding CFU data shown (right)