fluoxetine and semaglutide Fluoxetine: Understanding Their Impact on Weight Loss and Mental Health How Do Semaglutide and SSRIs

Kelly Tenbrink and Dr

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The largest psychiatric safety meta-analysis to date found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall ( Pierret et al., JAMA Psychiatry, 2025 ), and a post-hoc analysis of the major semaglutide weight management trials found no differences in depression, suicidal ideation, or suicidal behavior compared to placebo ( Wadden et al., JAMA Internal Medicine, 2024 )

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Comparative Efficacy: Weight Loss Outcomes (SURMOUNT vs STEP) There are no published head-to-head clinical trials comparing semaglutide and tirzepatide directly