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The peptides were eluted with a linear gradient of solvent B from 35% to 50% for 30 min

Side effects such as nausea or digestive discomfort often appear within the first 48 hours after a dose increase

The standard-curve plasma samples are then stored at 20C and further processed alongside the pharmacokinetic study samples [2]

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The reported outcome of this campaign was a candidate that retained agonist activity at amylin/calcitonin-family receptors while displaying a markedly extended pharmacokinetic profile in the authors' preclinical models, and reduced food intake in rodent models following administration