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Semaglutide encourages weight loss by mimicking a hormone called GLP-1

Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons

It is analogous to giving someone the latest iPad with only Solitaire installed. At present, the interaction and feedback loop between the user (the patient/physician team) and manufacturer (the pharma company) is virtually non-existent

Wegovy contains semaglutide, an active ingredient that acts exactly like that messenger, but louder and longer

Diabetes care, 48(9), 16071611

doi: Larson JM, Tavakkoli A, Drane WE, Toskes PP, Moshiree B