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2b, Supplementary Figure 1c)

Who Should NOT Take GLP-1 for Weight Loss

Tirzepatide activates both GLP-1 and GIP receptors to lower blood sugar and promote weight loss, but certain medical conditions, medications, and patient populations should not use this compound

The compound appears to act as both a substrate and inhibitor of these enzymes, which metabolize numerous medications

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doi: 10.1002/dmrr.3070 Summary Keywords GLP-1 receptor agonists, thyroid disorders, thyroid cancer, meta-analysis, randomized controlled trials Citation Hu W, Song R, Cheng R, Liu C, Guo R, Tang W, Zhang J, Zhao Q, Li X and Liu J (2022) Use of GLP-1 Receptor Agonists and Occurrence of Thyroid Disorders: a Meta-Analysis of Randomized Controlled Trials