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It depends on how severe the deficiency is, the dose, and how the body responds

Br J Cancer 119(6):663669 Kudo M et al (2018) Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

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As with any supplement, its important to talk with a healthcare professional to determine whether a vitamin B12 supplement is necessary for you