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Cuproptosis-related gene signatures, including ITGB6, LTBP1, FSTL1, CX3CR1, and AGR2, are significantly upregulated in DKD, serving as robust diagnostic biomarkers that correlate with immune cell infiltration and progressive tubulointerstitial damage (217)

Collagen supports skin structure and glutathione protects that structure from oxidative stress

Yeung et al., 2013

10.1016/j.biopha.2018.03.007 100 KhanN.MukhtarH

Ascorbic acid has also been studied in the therapeutic setting for cancer patients, considering that high doses act as pro-oxidants rather than antioxidants and can limit the glycolysis-dependent energy production of cancer cells by hindering transporter-mediated glucose intake (117, 123)