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The peptide's amino acid sequence, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, includes two D-amino acids (D-Trp and D-Phe), which confer resistance to enzymatic degradation and contribute to its receptor binding affinity
Liraglutide effects on epicardial adipose tissue micro-RNAs and intra-operative glucose control
Leventhal-Perek, S., Shani, M
Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1
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However, when the reduced affinity was accounted for, exendin-phe1 and, to a lesser extent, lixi-phe1, were more efficiently coupled to cAMP production than the -asp3 versions (Figure 6C)
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