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Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

The Role of Glutathione and Glutathione S-Transferases in Mercapturic Acid Biosynthesis

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By deploying an oral delivery mechanism, investigators can map localized enteric and adipocyte enzymatic inhibition against wider systemic metabolic adaptation loops