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84 The topical application of vasodilators provides pain relief in PDPN, suggesting a role for hypoxia and/or vascular dysfunction in the generation of neuropathic pain in DPN

doi:10.1056/NEJMoa1411892

This timeframe allows assessment of individual response, opportunity to adjust dosing, and generation of meaningful results without committing to an extended protocol

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Brown fat is specialized tissue that burns energy to generate heat this process is called non-shivering thermogenesis