DPP-4 is an integral membrane protein which has a widespread distribution, being expressed in numerous tissues including intestinal and renal brush border membranes, vascular endothelium, the liver and pancreas, glandular epithelial cells, and by cells of the immune system (where it is also known as the T-cell differentiation antigen, CD26)
They share a class mechanism and a broadly similar side effect profile, but their approved uses, dose ranges, and molecular structures are meaningfully different
Why the Purple Book Cannot Substitute for a BPCIA Intelligence Program As of 2023, a new provision, the Biological Product Patent Transparency (BPPT) provision, requires biosimilar originators to publish patent lists
Not a mild one, but fairly significant
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