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Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier
In addition, since we found a clear affinity of SNAC toward itself and semaglutide in both aqueous and hydrophobic environments, the co-aggregation of SNAC with semaglutide might also play an important role in helping to recruit the SNAC-bound semaglutide from the aqueous layer to the membrane (with the SNAC around the semaglutide fusing with membrane-bound SNAC)
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According to FDA labeling, tirzepatide must be protected from light, should never be frozen, and should not be shaken
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