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In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)

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GPLC and L -carnitine fumarate, while employed in certain situations such as improving athletic performance and mitochondrial function, have yet to show substantial differences in microbiota-related benefits when compared to LC itself