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Food and Drug Administration (FDA) accelerated approval for treating metabolic dysfunction-associated steatohepatitis (MASH), the first GLP-1 approved for this indication Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), is a serious condition that occurs when fat accumulates in the liver, causing inflammation and damage, such as scarring (fibrosis), cirrhosis or liver failure
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In particular we are intrigued by the accessibility of a large protein such as Fab 3F52 into a region of GLP-1R normally accessed by the activation determinants of GLP-1
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Enteroendocrine cells in terminal ileal Crohns disease
Once activated, this pathway encourages pulsatile GH release , leading to a downstream increase in Insulin-like Growth Factor 1 (IGF-1) production from the liver a key anabolic hormone responsible for muscle growth, fat metabolism, and cellular repair
