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Instead of B12, the propionibacterium then synthesises porphyrin, which can trigger an inflammatory reaction in the skin cells that ultimately leads to acne

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For diabetic wound healing, which is notoriously slow and prone to complications, GHK-Cu incorporated into collagen dressings produced dramatically better outcomes: higher glutathione and ascorbic acid levels at the wound site, better epithelialization, and significantly more active fibroblasts and mast cells compared to standard dressings

Links to the papers:

doi:10.3109/10408369609081009