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Although the nanoparticle drug delivery system was not initially designed for LDL-receptor-mediated brain targeting, it was later found that apolipoprotein E would be absorbed on the polysorbate 80 coated nanoparticles upon incubation of the nanoparticles with human plasma resulting in LDL-receptor mediated BBB crossing

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muciniphila ( Furthermore, the gut microbiota can metabolize choline into trimethylamine (TMA), which the body absorbs