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Sagulkoo P, Plaimas K, Suratanee A, Colado Simo AN, Vissoci Reiche EM, Maes M

Some patients transition to a maintenance dose, while others successfully taper off medication entirely after building sustainable habits

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All TPP-dependent enzymes contain a highly similar TPP-binding domain and its lack in the TKTL1 encoded protein strongly suggests that it is unlikely that TKTL1 is a TPP-dependent protein capable of catalyzing the transketolase reaction

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References: High delta sleep-inducing peptide-like immunoreactivity in plasma in suicidal patients with major depressive disorder