The pivotal STEP (Semaglutide Treatment Effect in People with obesity) clinical trials, which enrolled over 4,500 participants, did not identify iron deficiency as a significant safety concern
UACR, urinary albumin-to-creatinine ratio
However, current evidence on GLP-1 agents is largely observational and hypothesis-generating
If amycretin's early data holds in phase 3, its oral availability could make it the preferred option
The stimulatory effect of triagonist on GSIS surpassed that of the two glucose-lowering drugs, semaglutide and tirzepatide, in WT mouse islets (Fig
The dysregulation of these neural mechanisms might contribute to renal sodium and fluid retention associated with HF