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Stimulates Insulin Release (Smartly) After meals, Trulicity stimulates the pancreas to release more insulin, the hormone that transfers sugar from the blood into the cells

First disclosed by Eli Lilly investigators in 2018 under the development code LY3298176, tirzepatide marked a deliberate departure from decades of incretin research that had focused almost exclusively on GLP-1 mono-agonism

Focus on maintaining a balanced diet with adequate protein and nutrient intake, managing stress effectively, and working with a registered dietitian to ensure proper nutrition despite reduced appetite

These effects help regulate blood glucose levels while also supporting appetite control and reduced caloric intake

Engelhardt B, Coisne C