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2 Rendon MI

CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens

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(2011) 15:Unit 15.10

Rigorous human studies are required to determine safety parameters, mechanistic specificity, and potential translational relevance before any clinical applications can be considered

Future studies should focus on the key pathological pathways of PH, screen specific microRNAs for MSC modification, and improve the pulmonary vascular-targeted homing capacity of MSCs via genetic engineering technologies